TNM staging of foregut (neuro)endocrine tumors: a consensus proposal including a grading system.

• The need for standards in the management of patients with endocrine tumors of the digestive system prompted the European Neuroendocrine Tumor Society (ENETS) to organize a first Consensus Conference, which was held in Frascati (Rome) and was based on the recently published ENETS guidelines on the diagnosis and treatment of digestive neuroendocrine tumors (NET). Here, we report the tumor-node-metastasis proposal for foregut NETs of the stomach, duodenum, and pancreas that was designed, discussed, and consensually approved at this conference. In addition, we report the proposal for a working formulation for the grading of digestive NETs based on mitotic count and Ki-67 index. This proposal, which needs to be validated, is meant to help clinicians in the stratification, treatment, and follow-up of patients.

Keyword

Digestive System Neoplasms

chemistry

classification

diagnosis

Humans

Lymph Nodes

chemistry

pathology

Mitotic Index

Neoplasm Metastasis

diagnosis

Neoplasm Staging

methods

standards

Neuroendocrine Tumors

chemistry

classification

diagnosis

Tumor Markers

Biological

analysis

neuroendocrine tumors

MEDICINE

Publication and Content Type

ref (subject category)

for (subject category)